By Tammy Preston, MS

Generic Name: Bupropion (bew-PROH-pee-on)

Brand Names: Wellbutrin®, Zyban®, Budeprion®, Aplenzin®, Voxra®

Manufacturers: GlaxoSmithKline Inc.

What is Wellbutrin®?
Wellbutrin® is an antidepressant that has shown promise in helping people with childhood and adult ADHD. Antidepressants are sometimes used in conjuction with stimulants (such as Adderall) or as a standalone treatment for sufferers of adult attention deficit hyperactivity disorder. As well, depression and adult ADHD often coexist, and this medication is useful for people dealing with both issues.

How Does Wellbutrin® Work?
It is not known exactly how Wellbutrin® works, but it is thought that it inhibits the reuptake to norepinephrine and dopamine, which creates feelings of enjoyment and motivation.

How Do I Take Wellbutrin®?
Normally Wellbutrin® XR (extended release) is used as this ensures the medication remains effective all day, as well as reduces incidences of side effects.

Is Wellbutrin® Effective for Adult ADHD?
In a double-blind, placebo-controlled, randomized trial of 40 patients, Wellbutrin® showed a statistically significant effect in improving symptoms of people with adult ADHD.

That being said, Wellbutrin® is normally on tried after stimulants such as Adderall have been tried as stimulants are normally more effective in treating adult ADHD.

Wellbutrin® Side Effects
The biggest side effect of Wellbutrin® is the possibility of seizures. This risk is mitigated by using the lowest possible effective dose.

Pregnancy Category C
Women who are pregnant or may become pregnant should not use Wellbutrin®.

Wilens, et al. (2001), A Controlled Clinical Trial of Bupropion for Attention Deficit Hyperactivity Disorder in Adults, Am J Psychiatry 2001;158:282-288


  1. I have been on Adderall for 1 1/2 years now and it has changed my life! I am also taking Lexapro w/it. I did not know that wellbrutrin could possibly work better w/adderall. Anyone have any info or advice? My email is ddaugherty91861@yahoo.com

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