Adderall

Adderall

By Tammy Preston, MS

Brand Names: Adderall®, Adderall XR®

Generic Name: amphetamine (am-FET-uh-meen) with dextroamphetamine (dex-trow-am-FET-uh-meen)

Manufacturer: Shire Pharmaceuticals

Adderall® for Adults

Adderall® is a medication that must be prescribed by a doctor and is the brand name for a combination of amphetamine salts that function as central nervous system (CNS) stimulants, and have been FDA approved for the treatment of both childhood and adult attention deficit hyperactivity disorder (ADHD) as well as narcolepsy in adults.

Adderall® is now available in generic versions. Generic Adderall® is offered by Ranbaxy, Sandoz, and Teva Pharmaceutical.

What Is Adderall XR®?

Adderall® is now available in an extended release version that lasts for 24 hours, called Adderall XR® (an abbreviation for eXtended Release). Adderall XR® is an extended-release version of the drug that only needs to be taken once daily and is only indicated for childhood and adult ADHD, not narcolepsy. The XR formulation is still patented, meaning that it will not be available in generic form until at least 2019.

How Adderall® Works

Although it is not known exactly how Adderall® works, it is believed to increase the flow of the neurotransmitters dopamine and norepinephrine, chemicals that carry the signal between neurons (cells of the nervous system). This can result in an increase in a person’s ability to focus over extended periods of time.

Adderall® and Adderall XR® Dose

Adderall® is an oral mediation available in capsule form. The individual dosages for both Adderall® and Adderall XR® range from 5 – 30 milligrams (mg).

Time for Adderall® to take Effect

Although the time required for Adderall® to take effect may be different for each individual, instant-release drugs in this class generally take 1 – 3 hours. The amount of instant release Adderall® in the bloodstream peaks at about 3 hours. Adderall XR® lasts 24 hours, with the dose peaking about 8 hours after it is taken.

Is Adderall® and Adderall XR® Effective for Adult ADHD?

Adderall® has been used to treat ADHD in both children and adults for many years. In 2004, the Harvard investigators involved in analysis of Adderall XR® Phase III trials in adults concluded that the drug significantly improved subjects’ ability to maintain focus, concentrate, and pay attention for longer periods of time [1].

What is the Effect of Adderall® for Adult ADHD on Sports Performance?

Stimulants used in Adderall® have been shown to improve sports performance, particularly maximum heart rates and time to exhaustion during exercise.

Adderall® and Adderall XR® Minor Side Effects
Adderall® and Aderall XR® are generally considered safe and effective for adults. Common side effects are similar to those typically associated with the use of stimulants, and include:
· Dry mouth
· Loss of appetite
· Difficulty falling asleep
· Weight loss

Adderall® and Adderall XR® Precautions
Addiction & Abuse
Studies have been done to address concern that use of stimulant medications may lead to later drug dependency and abuse. Although untreated adult ADHD has been linked to an increased risk of substance abuse later in life [2], the likelihood of future drug abuse disorder is actually decreased when adult ADHD is properly treated [3].

Still, because Adderall® and Aderall XR® are amphetamines and stimulants, there is the potential for abuse. So this medication is not recommended for people who have a history of drug abuse.

Cardiac Precautions
Adderall® and other amphetamines may not be right for you if you have a history of heart problems, such as hardened arteries (arteriosclerosis), heart disease, high blood pressure (hypertension), or any other pre-existing cardiac condition.

Other Precautions
The drug is also not recommended for people with overactive thyroid, glaucoma, epilepsy and seizure disorders, severe anxiety or agitation and those who have taken MAO inhibitors within the past two weeks. Before taking Adderall® or Aderall XR®, be sure to tell your doctor if you have any of these problems.

Pregnancy Category C
Like all other adult ADHD medications, Adderall® and Aderall XR® are considered “category C” medications, which means that although no human studies have been done, based on animal studies it is thought that they may be harmful to an unborn baby.

This drug can also pass into breast milk and may be harmful to your baby if you nurse. Be sure to tell your doctor if you are pregnant or plan to become pregnant while you are being treated for adult ADHD.

Total Treatment of Adult Attention Hyperactivity Disorder
Adderall®, Aderall XR®, or any medication used to treat Adult ADHD, should be used as a part of a total treatment program. Comprehensive treatment of the adult ADHD often includes education, support groups, regular doctor appointments and therapy or counseling.

Adderall Withdrawal
If you stop taking Adderall, you may well end up with withdrawal symptoms. Symptoms are worse the longer you have been taking Adderall and the higher the dose you were taking. The main withdrawal symptom is extreme fatigue. Other withdrawal symptoms include negative mood, ranging from lack of motivation to depression. Symptoms can last from a few days to a few months.

Adderall Shortages
There is currently a shortage of Adderall in the United States. Adderall has been added to the official FDA drug shortages list. Many people with adult ADHD have, unfortunately, shown up at their local pharmacy to find that the pharmacy is out of stock. The reason for the shortage is that the DEA sets quotas for how much of various drug ingredients can be manufactured each year. As a result, not enough has been produced to meet the growing demand for Adderall.

Anecdotally, we have heard that pharmacies in ethnic neighborhoods are more likely to have Adderall in stock, in case you are having trouble finding it near you.

Share Your Experiences!
What have your experiences with Adderall been? Let us know about any successes or problems you’ve had taking Adderall for adult ADHD in the comments.

Sources
1. Biederman, J, M.D. (2004) Long-Term Safety and Efficacy of Mixed Amphetamine Salts Extended-Release for Adult ADHD. APA Presentation # 106
2. Richardson. (2005) When Too Much Isn’t Enough, Ending The Destructive Cycle of AD/HD and Addictive Behavior, Pinon Press
3. Wilens, et al. (2003) Does Stimulant Therapy of Attention-Deficit/Hyperactivity Disorder Beget Later Substance Abuse? A Meta-analytic Review of the Literature, Pediatrics Vol. 111 (1).
4. Shire US Inc., Prescribing Information sheet for Adderall XR.

Comments

  1. mr. anon says:

    I’ve been on it for two weeks. I’m having trouble figuring out the best dosage. My tolerance seems out of control already, I should give myself more days off the drug. Also having trouble managing my time. I’ll be engrossed in something (like writing online comments, trivia games) and be entranced for hours. But when I do study or read, I get it done. I’m worried that I don’t get enough calories in a day as my appetite is all screwed up. I go all day without food and still don’t have much of an appetite. Thank god for bananas, cereal and meal replacement shakes. The level of concentration is unreal though. I can troubleshoot the side effects in time.

  2. I am 33 years old, I was prescribed Adderal XR for inattentive ADD on Monday, took it Tuesday am and felt GREAT! I was shocked at how much I got done that day! I felt like I was really able to focus and was really pleased with the results! On Wednesday and Thursday began to feel mentally bogged down by noon or so, I was forgetting things and felt really sleepy around 5pm, by dinner time I felt anxious with a huge headache and just felt unfocused and tired. I just don’t know why I felt so great the first day and not so much now? Should I keep taking it or try something else this early on? My primary care doctor said I can try Concerta but should I give up on Adderal so soon?

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